This article discusses the introduction of DMS Irrigation Solution (Doxycycline, Metronidazole and Saline). It is an antibiotic solution, which can be pushed beyond the Periapical region to treat the Perio-Endo Lesions, Furcation, Fistula and even a big cyst of diameter 10 to 12 cm without causing any complications. The case study has been done in Sabya General Hospital, Jizan, Saudi Arabia in patients of the age group 18 to 55 after their proper consent. Only female cases were taken up for the study. Fifty cases were treated and followed up. Among them 20 cases had periodontitis and all of these had history of diabetes. During this procedure the DMS irrigation is used which directly flushes the microbes providing enough dilution, irrigation and initiates the process of healing, revascularization, regeneration and epithelialization of the wound. Delivery system seems to be an efficient system in treating the lesions; even of bigger diameters and DMS, as an irrigation seems to be the most appropriate additional irrigation besides the conventional ones used in dentistry.

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Alagille syndrome (Alagille-Watson syndrome) is an autosomal dominant genetic disorder that affects the liver, heart, kidney and other systems of the body. Major contributors to morbidity arise from bile duct paucity or cholestatic liver disease, underlying cardiac disease. Males and females are affected equally. Problems associated with the disorder generally become evident in infancy or childhood in our case at birth. Prevalence of this syndrome is 1; 100,000 live births. Growth failure, delayed puberty and malnutrition are common in children with Alagille syndrome. Children with Alagille syndrome have worse growth failure than children with other chronic liver diseases, such as biliary atresia.

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This is the right foot of a 48 years old female suffering from Type 2 DM for last one decade. She had a blister on it which became painful and grayish four days after it erupted. She had used a hot water bottle at night to tackle the extreme cold in winter in Kashmir. Can you guess what has happened? 

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SEGLUROMET is a combination of ertugliflozin, a sodium glucose co-transporter 2 (SGLT2) inhibitor, and metformin, a biguanide, indicated as an adjunct to diet and exercise to improve glycemic control in adults with type 2 diabetes mellitus who are not adequately controlled on a regimen containing ertugliflozin or metformin, or in patients who are already treated with both ertugliflozin and metformin.

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Use of Acid-Suppressive Drugs, Antibiotics in Infancy Linked to Increased Allergy Risk JAMA Pediatrics

Heart Failure Patients, Sacubitril/Valsartan Improves Physical and Social Activities Better Than Enalapril JAMA Cardiology 

Boys Who Lose Excess Weight Lower Their Risk for Developing Type 2 Diabetes NEJM

COPD Risk Factors Evident Early in Life Lancet Respiratory Medicine

Physician's First Watch coverage of COPD guidelines