Physicians Academy
Established in December 2006 by the Kashmir Academy Of Private Physicians
Table Of Contents
Editorial :
 The Real Paradigm Shift in Management of T2DM
Article 1 :
 Introduction of DMS irrigation to heal Endo–Perio lesions and Cysts
Article 2 :
 Alagille Syndrome in a Neonate
Picture of The Month :
 POTM-April 2018
Drug Update :
 SEGLUROMET (ertugliflozin+metformin)
Abstracts from Other Journals :
 Abstracts from Other Journals-April 2018

Locations of visitors to this page
Mar 2018 ( Volume -12 Number -3)

Abstracts from Other Journals
Abstracts from Other Journals-March 2018
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MARCH 2018

Abstracts from Other Journals

Do Cell Phones Cause Cancer? More Inconclusive Findings

Two draft reports from the National Toxicology Program (NTP), released on Friday, offer mixed findings on a potential association between cell phone use and cancer.

Researchers conducted studies in which rats and mice were exposed to varying levels of radiofrequency radiation (RFR) for roughly 9 hours a day for up to 2 years. Among the findings:

  • In male rats, the incidence of malignant schwannomas of the heart increased with increasing levels of RFR exposure beyond that allowed by cell phones.
  • There was no association between RFR and malignant schwannomas in female rats or in mice of either sex.
  • In both rats and mice, there were significant increases in tumors found in other organs, such as the brain, prostate, liver, and pancreas. These findings, however, were considered equivocal.
  • Ventricular cardiomyopathy increased with RFR exposure in rats but not mice.

"The levels and duration of exposure to RFR were much greater than what people experience with even the highest level of cell phone use, and exposed the rodents' whole bodies. So, these findings should not be directly extrapolated to human cell phone usage," said an NTP senior scientist in a news release. "We note, however, that the tumors we saw in these studies are similar to tumors previously reported in some studies of frequent cell phone users."

National Institute of Environmental Health Sciences news release (Free)

NTP draft reports (Free PDF)

Background: Physician's First Watch coverage of earlier NTP program report (Free)

Former Google, Facebook Employees Launch Fight Against Ills of Social Media

Former insiders at Facebook and Google, among others, have together formed a coalition aimed at combating the ill effects of social media use, the New York Times reports. Among the reported effects — depression, anxiety, stress, and narcissism with excessive Facebook use.

The coalition, called the Center for Humane Technology, says its focus is "reversing the digital attention crisis and realigning technology with humanity's best interests." One of its plans is to work with the nonprofit Common Sense Media to launch a lobbying effort and ad campaign against tech addiction.

One participant — an early investor in Facebook — told the Times: "Facebook appeals to your lizard brain — primarily fear and anger. And with smartphones, they've got you for every waking moment." He added, "This is an opportunity for me to correct a wrong."

New York Times story (Free)

Center for Humane Technology website (Free)

Background: NEJM Journal Watch Psychiatry recent coverage of social media addiction (Your NEJM Journal Watch subscription required)

Drinking Hot Tea Linked to Esophageal Cancer in High-Risk Adults

Daily consumption of hot or burning-hot tea is associated with increased risk for esophageal cancer in adults who also smoke or drink alcohol daily, a study in the Annals of Internal Medicine suggests.

Over 450,000 Chinese adults completed baseline questionnaires about tea drinking, smoking, and alcohol consumption. During a median 9 years' follow-up, esophageal cancer was diagnosed in roughly 1100 men and 630 women.

Among the findings, with nonsmokers who drank tea less than daily and consumed under 15 g alcohol daily as the reference group:

  • Those who drank hot or burning-hot tea daily and currently smoked had a 56% increased risk for esophageal cancer.
  • Those who drank hot/burning-hot tea daily and consumed at least 15 g alcohol daily (just over one standard drink) had more than a twofold increased risk.
  • Combining all three risk factors increased risk fivefold.

Editorialists write, "Perhaps those of us who drink hot beverages often should be prudent and wait for the liquid to cool a bit first. However, the results of this study should not cause people to abandon their favorite beverage."

Annals of Internal Medicine article (Free abstract)

Annals of Internal Medicine editorial (Subscription required)

Background: Physician's First Watch coverage of 2016 WHO statement on hot beverages and esophageal cancer (Free)

Background: NEJM Journal Watch Cardiology coverage of study suggesting tea is heart-healthy (Your NEJM Journal Watch registration required)

Canagliflozin Associated with Fewer Heart Failure Admissions in Type 2 Diabetes

Canagliflozin — a sodium-glucose cotransporter 2 inhibitor used to treat type 2 diabetes — is associated with lower risk for heart failure admission relative to other diabetes drugs, suggests an observational study in The BMJ.

Using health insurance data, U.S. researchers studied nearly 80,000 adults with diabetes and without cardiovascular disease who began treatment with canagliflozin; a dipeptidyl peptidase-4 (DPP-4) inhibitor (e.g., saxagliptin); a glucagon-like peptide-1 (GLP-1) receptor agonist (e.g., liraglutide); or a second- or third-generation sulfonylurea (e.g., glimepiride). Canagliflozin recipients were matched with patients who began each of the other drug classes.

During follow-up, the incidence of heart failure admission was lower with canagliflozin (7.3–8.9 events per 1000 person-years) than with DPP-4 inhibitors (12.8 per 1000), GLP-1-receptor agonists (12.4), or sulfonylureas (14.4). A second primary endpoint — a composite of myocardial infarction or stroke — did not differ significantly between canagliflozin and the other groups.

The researchers conclude: "Our investigation shows the potential cardiovascular benefits of canagliflozin versus other diabetes drugs as used in routine care."

The BMJ article (Free)

Background: NEJM Journal Watch Cardiology coverage of canagliflozin vs. placebo (Your NEJM Journal Watch subscription required)

2018 Pediatric Immunization Schedule Published

The CDC's Advisory Committee on Immunization Practices has published its annual immunization schedule for children and adolescents through age 18 years.

Here are some of the adjustments from last year, as noted in Pediatrics:

  • A third dose of the measles-mumps-rubella vaccine may be given during a mumps outbreak to children at least 12 months old.
  • The live attenuated influenza vaccine (FluMist) is not recommended for the current flu season.
  • For infants born to mothers who are negative for hepatitis B surface antigen (HBsAg), those weighing less than 2000 grams should receive a dose of the hepatitis B vaccine at a chronological age of 1 month or at hospital discharge. Those weighing more should be vaccinated within 24 hours after birth. (For infants born to women who are positive for HBsAg, recommendations have not changed.)

Pediatrics article (Free)

Full immunization schedule on CDC website (Free PDF)

Background: Physician's First Watch coverage of 2018 adult immunization schedule (Free)






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